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Combined presence of MAFLD and alcohol use showed an important synergistic detrimental effect in the younger population, which attenuated by increasing age category: for age-group A/B/C/D: adjusted Hazard Ratio (aHR) 2.34 (1.3-4.1), p=0.003, aHR 2.05 (1.3-3.2) p=0.001, aHR 1.35 (1.0-1.8) p=0.049 and aHR 1.24 (0.9-1.6) p=0.053, respectively (Table)

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Once inside, iron participates in Fenton reactions, generating highly reactive free radicals, such as hydroxyl radicals